@article { author = {Ouyang, Shao-Bo and Wang, Jun and Zhao, Si-Yu and Zhang, Xian-Hua and Liao, Lan}, title = {CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance}, journal = {Iranian Journal of Basic Medical Sciences}, volume = {21}, number = {11}, pages = {1186-1191}, year = {2018}, publisher = {Mashhad University of Medical Sciences}, issn = {2008-3866}, eissn = {2008-3874}, doi = {10.22038/ijbms.2018.30347.7313}, abstract = {Objective(s): Circular RNAs (circRNAs), a new class of non-coding RNAs, have emerged as important regulators during tumorigenesis. However, the functions of circRNAs have not been completely clarified in the progression of cancers. In our study, a novel circRNA hsa_circ_0109291 was investigated in oral squamous cell carcinoma (OSCC) tissues and cell lines. Materials and Methods: The expression profile of circRNAs in OSCC tumor tissues was performed by high-throughput sequencing. The CCK-8 wound healing and apoptosis assay were measured in OSCC cell lines after transfection with si-0109291 or si-NC. Results: We discovered that hsa_circ_0109291 was significantly increased in OSCC tissues and cell lines compared with their corresponding control group. Knockdown of hsa_circ_0109291 inhibited proliferation and migration of OSCC cell lines in vitro. In addition, inhibition of hsa_circ_0109291 dramatically induced apoptosis of OSCC cells. We further found that high hsa_circ_0109291 levels in OSCC patients resulted in a poorer prognosis than in patients with low hsa_circ_0109291 levels. Conclusion: These findings indicated that hsa_circ_0109291 correlated with the progression of OSCC and might be a new therapeutic target for the treatment of OSCC.}, keywords = {Apoptosis,CircRNA,Hsa_circ_0109291,Oral squamous cell carcinoma,Prognosis}, url = {https://ijbms.mums.ac.ir/article_11442.html}, eprint = {https://ijbms.mums.ac.ir/article_11442_340490f89f0e7ec436fa4cd35b493c54.pdf} }