@article { author = {Khoshvaghti, Habib and Altunkaynak, Berrin Zuhal}, title = {The effects of bortezomib on the ovariectomy applied rat uterus: A histopathological, stereological and immunohistochemical study}, journal = {Iranian Journal of Basic Medical Sciences}, volume = {21}, number = {11}, pages = {1118-1125}, year = {2018}, publisher = {Mashhad University of Medical Sciences}, issn = {2008-3866}, eissn = {2008-3874}, doi = {10.22038/ijbms.2018.24756.6152}, abstract = {Objective(s): In this study, potential protective effects of Bortezomib (Bort), as a proteasome inhibitor, were investigated on the uterus of ovariectomized rats by histological, morphometric and immunohistochemical methods.Materials and Methods: In this study, 18 Sprague dawley strain female rats (12 weeks old, 250-300 g body weight) were used. Animals in the control group (Cont, n=6) were not exposed to any treatment. Ovariectomy was performed on the experimental groups. They (n=12) were divided into ovariectomy (Ovt, n=6) and Bortezomib (Bort, n=6) subgroups. Twelve weeks later, the rats were perfused. Then, uterine tissues were removed and examined by morphometrical, and light and electron microscopy methods. In addition, immunoreactivity of nuclear factor-kappa (NF-κB) was evaluated.Results: Morphometric and histopathological evaluations showed that Bort was effective in the uterus and protects the layer structures and the cells.Conclusion: In the light of these findings, we suggest that for proteasome inhibitor particularly Bort is thought to be useful through proteasome inhibition and NF-κB pathway.}, keywords = {Bortezomib Microscopy Ovariectomy Rat Stereology,Uterus}, url = {https://ijbms.mums.ac.ir/article_11546.html}, eprint = {https://ijbms.mums.ac.ir/article_11546_f392db9030f233af4ece5140662beb4b.pdf} }