@article { author = {Verma, Priya and Singh, Poonam and S. Gandhi, Behrose}, title = {Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice}, journal = {Iranian Journal of Basic Medical Sciences}, volume = {17}, number = {4}, pages = {307-311}, year = {2014}, publisher = {Mashhad University of Medical Sciences}, issn = {2008-3866}, eissn = {2008-3874}, doi = {10.22038/ijbms.2014.2590}, abstract = {Objective(s):Bacopa monnieri (BM),a traditional ayurvedic medicine,is a well-known memory enhancer. We have explored the role of BM against decabrominated diphenyl ether (PBDE-209)-induced alterations in neonate and young female mice. Materials and Methods: Mice were orally administered with B. monnieri at the doses of 40, 80 or 120 mg/kg body weight along with PBDE-209 (20 mg/kg body weight) from postnatal day (PND) 3-10. Levels of malondialdehyde, protein carbonyl and activities of superoxide dismutase and glutathione peroxidase were measured at both ages. The correct choices and reference/working memory errors of young mice were evaluated by Morris water and radial arm maze. Results: The results showed that BM at the dose of 120 mg/kg significantly (P<0.05) restored the levels of oxidants and the activities of antioxidant enzymes in frontal cortex and hippocampus of neonates against PBDE-209-induced toxicity.   Conclusion: BM plays a neuroprotective role against PBDE-209-induced alterations in oxidative            status.}, keywords = {Bacopa monnieri,Oxidative stress,PBDE-209,Reference memory,Working memory}, url = {https://ijbms.mums.ac.ir/article_2590.html}, eprint = {https://ijbms.mums.ac.ir/article_2590_ad11672022a6d745cdf185a8d5ea1088.pdf} }