@article { author = {Eftekharzadeh, Mina and Nobakht, Maliheh and Alizadeh, Akram and Soleimani, Mansooreh and Hajghasem, Mahmood and Kordestani Shargh, Bahareh and Karkuki Osguei, Nushin and Behnam, Babak and Samadikuchaksaraei, Ali}, title = {The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease}, journal = {Iranian Journal of Basic Medical Sciences}, volume = {18}, number = {5}, pages = {520-525}, year = {2015}, publisher = {Mashhad University of Medical Sciences}, issn = {2008-3866}, eissn = {2008-3874}, doi = {10.22038/ijbms.2015.4417}, abstract = {Objective(s): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. Materials and Methods: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of β amyloid into the hippocampus for histological and immunohistochemical studies. Results: Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. Conclusion: Our results showed that BMSCs intratechal administration could be a promising method for treatment ofAlzheimer’s disease in rat model.}, keywords = {Alzheimer’s disease,Bone marrow stromal cells,Intrathecal delivery,Rat model}, url = {https://ijbms.mums.ac.ir/article_4417.html}, eprint = {https://ijbms.mums.ac.ir/article_4417_f470ff995a923aa3a887dbefc4d27684.pdf} }