@article { author = {Farjah, Gholam Hossein and Salehi, Shadi and Ansari, Mohammad Hasan and Pourheidar, Bagher}, title = {Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats}, journal = {Iranian Journal of Basic Medical Sciences}, volume = {20}, number = {3}, pages = {334-337}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2008-3866}, eissn = {2008-3874}, doi = {10.22038/ijbms.2017.8364}, abstract = {Objective(s): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. Results: The mean motor deficit index (MDI) scores were significantly lower in the saffron extract groups than in the NS group at 48 hr after spinal cord ischemia (P<0.001). Saffron extract groups significantly decreased plasma level of malondialdehyde than in the NS Group (P<0.05). The number of motor normal neurons was significantly greater in the high saffron extract group than in the NS and low saffron group (P<0.05). Conclusion: These data suggest that a saffron extract may protect spinal cord neurons from I/R injury.}, keywords = {Ischemia,Reperfusion,Spinal Cord,Saffron extract}, url = {https://ijbms.mums.ac.ir/article_8364.html}, eprint = {https://ijbms.mums.ac.ir/article_8364_b85d5b5c30289647718f2d695bde1869.pdf} }