%0 Journal Article %T CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Ouyang, Shao-Bo %A Wang, Jun %A Zhao, Si-Yu %A Zhang, Xian-Hua %A Liao, Lan %D 2018 %\ 11/01/2018 %V 21 %N 11 %P 1186-1191 %! CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance %K Apoptosis %K CircRNA %K Hsa_circ_0109291 %K Oral squamous cell carcinoma %K Prognosis %R 10.22038/ijbms.2018.30347.7313 %X Objective(s): Circular RNAs (circRNAs), a new class of non-coding RNAs, have emerged as important regulators during tumorigenesis. However, the functions of circRNAs have not been completely clarified in the progression of cancers. In our study, a novel circRNA hsa_circ_0109291 was investigated in oral squamous cell carcinoma (OSCC) tissues and cell lines. Materials and Methods: The expression profile of circRNAs in OSCC tumor tissues was performed by high-throughput sequencing. The CCK-8 wound healing and apoptosis assay were measured in OSCC cell lines after transfection with si-0109291 or si-NC. Results: We discovered that hsa_circ_0109291 was significantly increased in OSCC tissues and cell lines compared with their corresponding control group. Knockdown of hsa_circ_0109291 inhibited proliferation and migration of OSCC cell lines in vitro. In addition, inhibition of hsa_circ_0109291 dramatically induced apoptosis of OSCC cells. We further found that high hsa_circ_0109291 levels in OSCC patients resulted in a poorer prognosis than in patients with low hsa_circ_0109291 levels. Conclusion: These findings indicated that hsa_circ_0109291 correlated with the progression of OSCC and might be a new therapeutic target for the treatment of OSCC. %U https://ijbms.mums.ac.ir/article_11442_340490f89f0e7ec436fa4cd35b493c54.pdf