%0 Journal Article %T The Extract of Crocus sativus and Its Constituent Safranal, Affect Serum Levels of Endothelin and Total Protein in Sensitized Guinea Pigs %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Gholamnezhad, Zahra %A Koushyar, Hamed %A Byrami, Goltaj %A Boskabady, Mohammad Hossein %D 2013 %\ 09/01/2013 %V 16 %N 9 %P 1022-1026 %! The Extract of Crocus sativus and Its Constituent Safranal, Affect Serum Levels of Endothelin and Total Protein in Sensitized Guinea Pigs %K Asthma Crocus sativus Endotheline Inflammation Safranal Sensitization %R 10.22038/ijbms.2013.1685 %X   Objective(s): The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined.   Materials and Methods: Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, three concentrations of extract and one concentration of dexamethasone, (n=6, for all groups) and serum levels of endotheline-1 (ET-1) and total protein (TP) were assessed. Results: Serum levels of ET-1 and TP in group S were significantly higher than control group (P Conclusion: A preventive effect of the extract of C. sativus and its constituent safranal on serum inflammatory markers in sensitized guinea pigs was shown. %U https://ijbms.mums.ac.ir/article_1685_ae4fd56a01345f39e341f37664d44da1.pdf