%0 Journal Article %T Anti-inflammatory, Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Elizabeth Mathew, Jessy %A Keloth Kaitheri, Srinivasan %A DinakaranVachala, Seekarajapuram %A Jose, Magi %D 2011 %\ 09/01/2011 %V 14 %N 5 %P 422-427 %! Anti-inflammatory, Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica %K Anti-inflammatory %K Anti-antipruritic %K Aristolochia indica %K Mast cell stabilizing activity %R 10.22038/ijbms.2011.5037 %X Objective(s) Aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. In the present study different extracts of roots of A. indica were evaluated for their anti‌inflammatory, antipruritic and mast cell stabilizing activity. Materials and Methods Anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and antipruritic activity by examining the incidence of scratching behavior. Mast cell stabilizing activity was performed by compound 48/80 and sheep serum induced mast cell degranulation methods. Results The ethanol extract (300 mg/kg) and petroleum ether extract (100 mg/kg) were found to inhibit mast cell degranulation significantly equivalent to that of standard drug ketotifen (69%) by compound 48/80 model. In sheep serum model the ethanol extracts (150 and 300 mg/kg) and petroleum ether extract (100 mg/kg) showed good mast cell stabilizing activity (66-67%). Ethanol extract at 150 mg/kg showed 70% reduction of rat paw oedema and also significantly reduced the scratching response. Conclusion Results suggest A. indica has good mast cell stabilizing, anti-inflammatory and antipruritic activity. %U https://ijbms.mums.ac.ir/article_5037_c8b26b912041a7eb528e8ba2e822a129.pdf