%0 Journal Article %T Effect of ischemic preconditioning on the expression of c-myb in the CA1 region of the gerbil hippocampus after ischemia/reperfusion injury %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Young Lee, Hui %A Tae, Hyun-Jin %A Cho, Geum-Sil %A Kim, In Hye %A Hwi Cho, Jeong %A Ha Park, Joon %A Hyeon Ahn, Ji %A Hui Chen, Bai %A Shin, Bich-Na %A Won, Moo-Ho %A Woo Park, Chan %A Hwi Cho, Jun %A Yeol Seo, Jeong %A Lee, Jae-Chul %D 2016 %\ 06/01/2016 %V 19 %N 6 %P 624-631 %! Effect of ischemic preconditioning on the expression of c-myb in the CA1 region of the gerbil hippocampus after ischemia/reperfusion injury %K c-myb %K Cells in stratum pyramidale %K Delayed neuronal death %K Ischemic preconditioning %K Ischemia-reperfusion %K protection %R 10.22038/ijbms.2016.7130 %X Objective(s): In the present study, we investigated the effect of ischemic preconditioning (IPC) on c-myb immunoreactivity as well as neuronal damage/death after a subsequent lethal transient ischemia in gerbils. Materials and Methods: IPC was subjected to a 2 min sublethal ischemia and a lethal transient ischemia was given 5 min transient ischemia. The animals in all of the groups were given recovery times of 1 day, 2 days and 5 days and we examined change in c-myb immunoreactivity as well as neuronal damage/death in the hippocampus induced by a lethal transient ischemia. Results:A lethal transient ischemia induced a significant loss of cells in the stratum pyramidale (SP) of the hippocampal CA1 region at 5 days post-ischemia, and this insult showed that c-myb immunoreactivity in cells of the SP of the CA1 region was significantly decreased at 2 days post-ischemia and disappeared at 5 days post-ischemia. However, IPC effectively prevented the neuronal loss in the SP and showed that c-myb immunoreactivity was constitutively maintained in the SP after a lethal transient ischemia. Conclusion: Our results show that a lethal transient ischemia significantly decreased c-myb immunoreactivity in the SP of the CA1 region and that IPC well preserved c-myb immunoreactivity in the SP of the CA1 region. We suggest that the maintenance of c-myb might be related with IPC-mediated neuroprotection after a lethal ischemic insult. %U https://ijbms.mums.ac.ir/article_7130_abf6b260ad1d4b6f4533bbdf5bd04588.pdf