%0 Journal Article %T Development of 177Lu-phytate Complex for Radiosynovectomy %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Yousefnia, Hassan %A Jalilian, Amir Reza %A Bahrami-Samani, Ali %A Mazidi, Mohammad %A Ghannadi Maragheh1, Mohammad %A Abbasi-Davani, Fereydoun %D 2013 %\ 05/01/2013 %V 16 %N 5 %P 705-709 %! Development of 177Lu-phytate Complex for Radiosynovectomy %K Biodistribution Lutetium-177 Phytate Radiosynovectomy %R 10.22038/ijbms.2013.784 %X Objective(s): In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. Materials and Methods: Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. The product was converted into chloride form which was further used for labeling of 177Lu-phytate complex and checked using ITLC (MeOH: H2O: acetic acid, 4: 4: 2, as mobile phase). The complex stability and viscosity were checked in the final solution up to seven days. The prepared complex solution (100 µCi/100 µl) was injected intra-articularly to male rat knee joint. Leakage of radioactivity from injection site and its distribution in organs were investigated up to seven days. Results: The complex was successfully prepared with high radiochemical purity (>99.9 %). Approximately, the whole injected dose has remained in injection site seven days after injection. Conclusion: The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology %U https://ijbms.mums.ac.ir/article_784_6eec0c8aca6a827fc28fe7a9048a4042.pdf