%0 Journal Article %T Protective effect of metformin on D-galactose-induced aging model in mice %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Fatemi, Iman %A khaluoi, Amin %A Kaeidi, Ayat %A Shamsizadeh, Ali %A Heydari, Sara %A Allahtavakoli, Mohammad %D 2018 %\ 01/01/2018 %V 21 %N 1 %P 19-25 %! Protective effect of metformin on D-galactose-induced aging model in mice %K Aging %K D-galactose %K Metformin %K Mouse %K Oxidative stress %R 10.22038/ijbms.2017.24331.6071 %X Objective(s): Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. Materials and Methods: Met (1 and 10 mg/kg/p.o.), was administrated daily in D-gal-received (500 mg/kg/p.o.) mice model of aging for six weeks. Anxiety-like behavior, cognitive function, and physical power were evaluated by the elevated plus-maze, novel object recognition task (NORT), and forced swimming capacity test, respectively. The brains were analyzed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF). Results: Met decreased the anxiety-like behavior in D-gal-treated mice. Also, Met treated mice showed significantly improved learning and memory ability in NORT compared to the D-gal-treated mice. Furthermore, Met increased the physical power as well as the activity of SOD and BDNF level in D-gal-treated mice. Conclusion: Our results suggest that the use of Met can be an effective strategy for prevention and treatment of D-gal-induced aging in animal models. This effect seems to be mediated by attenuation of oxidative stress and enhancement of the neurotrophic factors. %U https://ijbms.mums.ac.ir/article_9918_8485c501384b5a8c6369749b6ca9f3f6.pdf