TY - JOUR ID - 10365 TI - Effect of maternal fluoxetine exposure on lung, heart and kidney development in rat neonates JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Taghizadeh Ghvamabadi, Razieh AU - Taghipour, Zahra AU - Hasanipoor, Mahsa AU - Khademi, Marzieh AU - Shariati, Mehdi AD - Department of Anatomy, School of Medicine; Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AD - Department of Physiology-Pharmacology, School of Medicine; Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Y1 - 2018 PY - 2018 VL - 21 IS - 4 SP - 417 EP - 421 KW - Fluoxetine KW - Heart KW - Kidney KW - Lung KW - SSRIs DO - 10.22038/ijbms.2018.27203.6650 N2 - Objective(s): Depression during pregnancy negatively affects fetal development. Fluoxetine as a selective serotonin reuptake inhibitor (SSRIs) is used for treatment of gestational depression. This study is trying to determine the effects of fluoxetine on the renal, heart and lung development.Materials and Methods: Fifteen pregnant rats were treated with fluoxetine at 7 mg/kg from days 0 to 21 of gestation. Immediately after born, heart and kidney samples were evaluated for genes expression and histological assessment. Lung sample were fixed for immunohistochemical study.Results: The gene expression of BMP7 and WNT4 were reduced in the kidney of fluoxetine-treated group (P-value<0.05), but in the heart of both groups no significant difference was found in gene expression (P-value>0.05). Histological assessment showed that the glomeruli of the kidneys in treated group are more primordial compared to control. There was a developmental deficiency in Bowman’s capsule, and the capsular space was not clear. The arrangements of the filaments, the position of the nucleus and cells morphology were normal in the hearts of both groups. Immunohistochemical analysis demonstrated that in the fluoxetine-exposed group HoxB5 is more expressed in the mesenchymal cells, but in the control group the expression is limited to alveolar cells.Conclusion: According to developmental changes in kidney, heart and lung, fluoxetine affects neonatal growth during pregnancy, which may lead to delay of some organs growth. So, it is essential to survey the roles of antidepressant drugs on fatal and neonatal development during pregnancy. UR - https://ijbms.mums.ac.ir/article_10365.html L1 - https://ijbms.mums.ac.ir/article_10365_da69f2e18f7ee4c7f21f33569bea2a26.pdf ER -