TY - JOUR ID - 10694 TI - Does inhibition of angiotensin function cause neuroprotection in diffuse traumatic brain injury? JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Khaksari, Mohammad AU - Rajizadeh, Mohammad Amin AU - Bejeshk, Mohammad Abbas AU - Soltani, Zahra AU - Motamedi, Sina AU - Moramdi, Fatemeh AU - Islami, Masoud AU - Shafa, Shahriyar AU - Khosravi, Sepehr AD - Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran AD - Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran AD - Physiology Research Center, Institute of Neuropharmacology, Afzalipour Faculty of Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran AD - Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Y1 - 2018 PY - 2018 VL - 21 IS - 6 SP - 615 EP - 620 KW - Angiotensin II receptor KW - Blood-brain barrier KW - Brain edema KW - Brain injury KW - Candesartan KW - Intracranial pressure KW - Lipid Peroxidation DO - 10.22038/ijbms.2018.26586.6512 N2 - Objective(s): Neuroprotection is created following the inhibition of angiotensin II type 1 receptor (AT1R). Therefore, the purpose of this research was examining AT1R blockage by candesartan in diffuse traumatic brain injury (TBI). Materials and Methods: Male rats were assigned into sham, TBI, vehicle, and candesartan groups. Candesartan (0.3 mg/kg) or vehicle was administered IP, 30 min post-TBI. Brain water and Evans blue contents were determined, 24 and 5 hr after TBI, respectively. Intracranial pressure (ICP) and neurologic outcome were evaluated at -1, 1, 4 and 24 hr after TBI. Oxidant index [malondialdehyde (MDA)] was determined 24 hr after TBI.Results: Brain water and Evans blue contents, and MDA and ICP levels increased in TBI and vehicle groups in comparison with the sham group. Candesartan attenuated the TBI-induced brain water and Evans blue contents, and ICP and MDA enhancement. The neurologic score enhanced following candesartan administration, 24 hr after TBI.Conclusion: The blockage of AT1R may be neuroprotective by decreasing ICP associated with the reduction of lipid peroxidation, brain edema, and blood-brain barrier (BBB) permeability, which led to the improvement of neurologic outcome. UR - https://ijbms.mums.ac.ir/article_10694.html L1 - https://ijbms.mums.ac.ir/article_10694_0a2ad7a22d187d10470a8d705e98ff92.pdf ER -