TY - JOUR ID - 13163 TI - Evaluation of the neuroprotective, anticonvulsant, and cognition-improvement effects of apigenin in temporal lobe epilepsy: Involvement of the mitochondrial apoptotic pathway JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Hashemi, Paria AU - Fahanik Babaei, Javad AU - Vazifehkhah, Somayeh AU - Nikbakht, Farnaz AD - Department of Physiology, School of Medicine and Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, Iran AD - Physiology Research Centre, Iran University of Medical Sciences, Tehran, Iran AD - Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Y1 - 2019 PY - 2019 VL - 22 IS - 7 SP - 752 EP - 758 KW - Apigenin KW - Anticonvulsant KW - Cognition KW - Cytochrome c KW - Neuroprotection KW - Temporal lobe epilepsy DO - 10.22038/ijbms.2019.33892.8064 N2 - Objective(s): Cognitive deficit is a common problem in epilepsy. A major concern emergent from the use of antiepileptic drugs includes their side effects on learning and memory. Herbal medicine is considered a complementary and alternative therapy in epilepsy. Apigenin is a safe flavone with antioxidant properties. However, there is little information about the beneficial effect of apigenin on cognition in epilepsy. Materials and Methods: For evaluating the anticonvulsant effect of apigenin in the kainite temporal epilepsy model, apigenin was orally administered at 50 mg/kg for six days. Reference and working memory were examined via the Morris water maze and Y-maze task spontaneously. Results: Results showed that apigenin had significant anticonvulsant activity (P<0.01) and restored the memory-deficit induced by kainic acid (P<0.05). Furthermore, apigenin significantly increased the number of living neurons in the hilus (P<0.001). Immunohistochemical analysis showed that apigenin reduced the release of cytochrome c (P<0.01), suggesting an inhibitory role in the intrinsic apoptotic pathway. Conclusion: These results suggest that apigenin restores memory impairment via anticonvulsant and neuroprotective activity. UR - https://ijbms.mums.ac.ir/article_13163.html L1 - https://ijbms.mums.ac.ir/article_13163_7cf851177534a02d69c45dd9ea6bb49d.pdf ER -