TY - JOUR ID - 16397 TI - Ginkgo biloba extract protects early brain injury after subarachnoid hemorrhage via inhibiting thioredoxin interacting protein/NLRP3 signaling pathway JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Du, Chuan AU - Xi, Chao AU - Wu, Chunxiao AU - Sha, Jichang AU - Zhang, Jinan AU - Li, Chao AD - Neurosurgery Department, Zhangqiu District People’s Hospital, Jinan 250200, China AD - Cardiothoracic Surgery Department, Zhangqiu District People’s Hospital, Jinan250200, China AD - Pharmacy Intravenous Admixture Services, Zhangqiu District People’s Hospital, Jinan 250200, China AD - ENT Department, Zhangqiu District People’s Hospital, Jinan 250200, China AD - Neurosurgery Department, Qilu Hospital of Shandong University, Jinan 250012, China Y1 - 2020 PY - 2020 VL - 23 IS - 10 SP - 1340 EP - 1345 KW - Brain injury KW - Ginkgo biloba extract KW - Inflammation KW - Oxidative stress KW - Subarachnoid Hemorrhage DO - 10.22038/ijbms.2020.42834.10090 N2 - Objective(s): To investigate the effect of Ginkgo biloba extract EGb761 in early brain injury (EBI) after subarachnoid hemorrhage (SAH) and its mechanism. Materials and Methods: The SAH rat model was constructed and pre-treated with EGb761.The neurological function, severity of SAH, water content of brain tissue, damage degree of the blood-brain barrier, related indexes of oxidative stress, and the level of inflammatory cytokines were compared among the groups. The expression of TXNIP/NLRP3 signaling pathway-related proteins in brain tissues was detected by Western blot.Results: After SAH modeling, the neurological function score was significantly reduced, the degree of brain injury, levels of oxidative stress, inflammatory factors, expression of NLRP3 and TXNIP were all increased. Compared with the SAH rats, the neurological function score of rats pre-treated by EGb761 was higher, the degree of brain injury, levels of oxidative stress and inflammatory factors, expression of NLRP3 and TXNIP were all lower. Conclusion: EGb761 could protect neurological injury after SAH and its mechanism may be that EGb761 could inhibit the activation of the TXNIP/NLRP3 signaling pathway and inflammatory reaction after oxidative stress. UR - https://ijbms.mums.ac.ir/article_16397.html L1 - https://ijbms.mums.ac.ir/article_16397_e5be9923cdf1ffb6c2ef76fe9a686e94.pdf ER -