TY - JOUR ID - 1981 TI - Evaluation of Serum Interleukins-6, 8 and 10 Levels as Diagnostic Markers of Neonatal Infection and Possibility of Mortality JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Boskabadi, Hassan AU - Maamouri, Gholamali AU - Tavakol Afshari, Jalil AU - Mafinejad, Shahin AU - Hosseini, Golkoo AU - Mostafavi-Toroghi, Hesam AU - saber, HamidReza AU - Ghayour-Mobarhan, majid AU - ferns, Gordon AD - Department of Pediatrics, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Immunology Research Center, Avicenna Research Institute. Mashhad University of Medical Sciences, Mashhad, Iran AD - Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Brighton & Sussex Medical School, Falmer, Brighton BN1 9PH, United Kingdom Y1 - 2013 PY - 2013 VL - 16 IS - 12 SP - 1232 EP - 1237 KW - Infection Interleukin-6 Interleukin-8 Interleukin-10 Newborn Sepsis DO - 10.22038/ijbms.2013.1981 N2 -   Objective(s): Bacterial infection contributes substantially to neonatal morbidity and mortality. Early diagnosis of neonatal sepsis is difficult because clinical signs are non-specific. We have evaluated serum IL-6, 8 and 10 as potential early diagnostic markers of neonatal infection and their relationship to mortality rate and poor prognosis.   Materials and Methods : A total of 84 infants, aged ≥ 72 hr were enrolled in this prospective case-control trial. The case group (n=41) included babies with clinical and laboratory findings compatible with sepsis and/or positive blood or cerebrospinal fluid cultures. The control group (n=43) included healthy infants. IL-6, 8 and 10 were measured for all infants. Receiver-operating characteristic (ROC) curves were used for the determination of thresholds. Results : Statistically significant differences were observed between control and case groups for serum median level of IL-6, 8 and 10 (P<0.001). IL-6 cut-off values of 10.85 Pg/ml for discriminating between cases and controls and 78.2 Pg/ml for predicting mortality are suggested. IL-8 at a cut-off value of 60.05 Pg/ml was valuable for differentiation of definite versus indefinite infection. Conclusion : Evaluating the IL-6, 8 and 10 simultaneously, could improve the sensitivity and specificity of early diagnosis of the neonatal sepsis. Regarding our results, interleukin 6 had the greatest value for predicting infection and possible mortality, whereas IL-8 was valuable for diagnosing definitive infection. UR - https://ijbms.mums.ac.ir/article_1981.html L1 - https://ijbms.mums.ac.ir/article_1981_1783d378408d933697fb8d82f793e9e7.pdf ER -