TY - JOUR ID - 2590 TI - Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Verma, Priya AU - Singh, Poonam AU - S. Gandhi, Behrose AD - Department of Zoology, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi 221005, India Y1 - 2014 PY - 2014 VL - 17 IS - 4 SP - 307 EP - 311 KW - Bacopa monnieri KW - Oxidative stress KW - PBDE-209 KW - Reference memory KW - Working memory DO - 10.22038/ijbms.2014.2590 N2 - Objective(s):Bacopa monnieri (BM),a traditional ayurvedic medicine,is a well-known memory enhancer. We have explored the role of BM against decabrominated diphenyl ether (PBDE-209)-induced alterations in neonate and young female mice. Materials and Methods: Mice were orally administered with B. monnieri at the doses of 40, 80 or 120 mg/kg body weight along with PBDE-209 (20 mg/kg body weight) from postnatal day (PND) 3-10. Levels of malondialdehyde, protein carbonyl and activities of superoxide dismutase and glutathione peroxidase were measured at both ages. The correct choices and reference/working memory errors of young mice were evaluated by Morris water and radial arm maze. Results: The results showed that BM at the dose of 120 mg/kg significantly (P<0.05) restored the levels of oxidants and the activities of antioxidant enzymes in frontal cortex and hippocampus of neonates against PBDE-209-induced toxicity.   Conclusion: BM plays a neuroprotective role against PBDE-209-induced alterations in oxidative            status. UR - https://ijbms.mums.ac.ir/article_2590.html L1 - https://ijbms.mums.ac.ir/article_2590_ad11672022a6d745cdf185a8d5ea1088.pdf ER -