TY - JOUR ID - 2925 TI - The effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Lale Ataei, Maryam AU - Ebrahimzadeh-bideskan, Ali Reza AD - Department of Anatomy and Cell biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2014 PY - 2014 VL - 17 IS - 6 SP - 411 EP - 418 KW - Apoptosis KW - Garlic KW - Hippocampus KW - Nano-silver DO - 10.22038/ijbms.2014.2925 N2 - Objective(s):The aim of this study was to investigate the effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus. Materials and Methods: Fifty pregnant wistar rats were randomly divided into five groups: 1- nano- silver (N.S) group; 30 mg/kg of N.S treated via gavage. 2- Control (C) group, administrated with distilled water via gavage. 3- N.S and garlic (N.S+G) group; N.S (30 mg/kg) and garlic juice (1 ml/100 g) treated via gavage simultaneously. 4- Garlic group (G); garlic juice (1 ml/100 g) administrated via gavage, 5- normal (N) without any intervention. All the interventions were done during pregnancy (21 days). Finally, the brains of rat offspring were removed to use for nano-silver level measurement and TUNEL staining. The mean of TUNEL positive cell numbers per unit area (NA) in different regions of hippocampus were compared in all animal groups. Results: The results revealed a significant increase of hippocampus nano-silver level in N.S and N.S+G groups comparing to N group (P<0.05) and a significant decrease in nano-silver level in N.S+G group comparing to N.S group (P<0.01). The number of TUNEL positive cells in the CA1, CA3, and DG fields of rat offspring hippocampus increased in N.S and N.S+G groups comparing to other ones, and also reduced significantly in N.S+G group comparing to N.S group (¥  P< 0.01). Conclusion: Our results showed that co-administration of nano-silver and garlic during pregnancy may lead to reduce nano-silver induced apoptotic cells in their offspring hippocampus.    UR - https://ijbms.mums.ac.ir/article_2925.html L1 - https://ijbms.mums.ac.ir/article_2925_14e0bf3eb79fedb7fb4c97a1b556df18.pdf ER -