TY - JOUR ID - 3035 TI - The effects of Eucheuma cottonii on alveolar macrophages and malondialdehyde levels in bronchoalveolar lavage fluid in chronically particulate matter 10 coal dust-exposed rats JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Kisno Saputri, Romadhiyana Kisno Saputri AU - Setiawan, Bambang AU - Nugrahenny, Dian AU - Kania, Nia AU - Sri Wahyuni, Endang AU - Widodo, M Aris AD - Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia AD - Department of Medical Chemistry and Biochemistry, Research Center for Toxicology, Cancer and Degenerative Disease, Medical Faculty, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia AD - Laboratory of Pharmacology, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia AD - Department of Pathology, Research Center for Toxicology, Cancer and Degenerative Disease, Ulin General Hospital, Medical Faculty, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia AD - Laboratory of Physiology; Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia Y1 - 2014 PY - 2014 VL - 17 IS - 7 SP - 541 EP - 545 KW - Alveolar macrophage KW - Coal dust KW - Eucheuma cottonii KW - Malondialdehyde DO - 10.22038/ijbms.2014.3035 N2 - Objective(s):To investigate the effect of Eucheuma cottonii on alveolar macrophages (AM) and malondialdehyde (MDA) levels in bronchoalveolar lavage fluids (BALF) in particulate matter 10 (PM10) coal dust-exposed rats. Materials and Methods: Ten groups, including a non exposed group and groups exposed to coal dust at doses of 6.25 (CD6.25), 12.5 (CD12.5), or 25 mg/m3 (CD25) an hour daily for 6 months with or without supplementation of ethanolic extract of E. cottonii at doses of 150 (EC150) or 300 mg/kg BW (EC300). The number of macrophages was determined using a light microscope. MDA levels were measured by TBARS assay. Results: EC150 insignificantly (P > 0.05) reduces the AM in CD groups compared to non treatment groups. EC150 and EC300 significantly (P < 0.05) decreased MDA levels in CD12.5 and CD25 groups relative to non treatment groups. Conclusion: E. cottonii attenuated oxidative stress in chronic exposure of PM10 coal dust. UR - https://ijbms.mums.ac.ir/article_3035.html L1 - https://ijbms.mums.ac.ir/article_3035_f5913ac76f14a98ba6462a69808cff7d.pdf ER -