TY - JOUR ID - 3450 TI - Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Hu, Liandong AU - Hu, Qiaofeng AU - Yang, Jianxue AD - 1 College of Pharmaceutical Sciences, Hebei University, Baoding, China 2 Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, China AD - College of Pharmaceutical Sciences, Hebei University, Baoding, China. NBP Pharmaceutical Company Limited, CSPC Pharmaceutical Group Limited, Shijiazhuang 052165, People’s Republic of China AD - 1 College of Pharmaceutical Sciences, Hebei University, Baoding, China.3 NBP Pharmaceutical Company Limited, CSPC Pharmaceutical Group Limited, Shijiazhuang 052165, People’s Republic of China Y1 - 2014 PY - 2014 VL - 17 IS - 10 SP - 760 EP - 766 KW - Ibuprofen KW - Microemulsion KW - Skin Permeability KW - Transdermal DO - 10.22038/ijbms.2014.3450 N2 - Objective(s):The objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability. Materials and Methods: Microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. The effects of oleic acid and surfactant mixture on skin permeation of ibuprofen were evaluated with excised skins. Results: The optimum formulation F3 consisting of 6% oleic acid, 30% Cremophor RH40/Transcutol P (2:1, w/w) and 59% water phase, showed a high permeation rate of 42.98 μg/cm2/hr. The mean droplet size of microemulsion was about 43 nm and no skin irritation signs were observed on the skin of rabbits. Conclusion: These results indicated that this novel microemulsion is a useful formulation for the transdermal delivery of ibuprofen. UR - https://ijbms.mums.ac.ir/article_3450.html L1 - https://ijbms.mums.ac.ir/article_3450_4d19d9c3f1512652651843aec5101b69.pdf ER -