TY - JOUR ID - 4417 TI - The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Eftekharzadeh, Mina AU - Nobakht, Maliheh AU - Alizadeh, Akram AU - Soleimani, Mansooreh AU - Hajghasem, Mahmood AU - Kordestani Shargh, Bahareh AU - Karkuki Osguei, Nushin AU - Behnam, Babak AU - Samadikuchaksaraei, Ali AD - Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran AD - Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Basic Sciences, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran AD - Eposcience Millennium Institute, Tehran, Iran AD - Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran Y1 - 2015 PY - 2015 VL - 18 IS - 5 SP - 520 EP - 525 KW - Alzheimer’s disease KW - Bone marrow stromal cells KW - Intrathecal delivery KW - Rat model DO - 10.22038/ijbms.2015.4417 N2 - Objective(s): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. Materials and Methods: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of β amyloid into the hippocampus for histological and immunohistochemical studies. Results: Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. Conclusion: Our results showed that BMSCs intratechal administration could be a promising method for treatment ofAlzheimer’s disease in rat model. UR - https://ijbms.mums.ac.ir/article_4417.html L1 - https://ijbms.mums.ac.ir/article_4417_f470ff995a923aa3a887dbefc4d27684.pdf ER -