TY - JOUR ID - 5052 TI - Liver Oxidative Stress after Renal Ischemia-Reperfusion Injury is Leukocyte Dependent in Inbred Mice JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Khastar, Hossein AU - Kadkhodaee, Mehri AU - Sadeghipour, Hamid reza AU - Seifi, Behjat AU - Hadjati, Jamshid AU - Najafi, Atefeh AU - Soleimani, Manoocher AD - School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran AD - Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Medicine, University of Cincinnati, MSB G259 OH, United States Y1 - 2011 PY - 2011 VL - 14 IS - 6 SP - 534 EP - 539 KW - Leukocyte KW - Liver KW - Oxidative stress KW - Renal ischemia DO - 10.22038/ijbms.2011.5052 N2 - Objective(s) There are some reports in recent years indicating that renal ischemia - reperfusion (IR) induces deleterious changes in remote organs such as liver. The aim of this study was to investigate whether leukocytes have a role on the induction of oxidative stress in liver after renal IR. Materials and Methods Inbred mice in IR donor group were subjected to renal IR injury. In sham donor group the procedure was almost the same except that ischemia was not induced. Then, mice were anesthetized and blood was collected. Leukocytes were isolated from donor groups and were then transferred to intact recipient mice (from IR donor mice to IR recipient mice and from sham donor mice to sham recipient mice). Results After 24 hr, hepatic superoxide dismutase (SOD) and catalase (CAT) activities decreased significantly in recipient mice that received leukocytes from IR donor mice in comparison to recipient mice received leukocytes from sham donor mice. Conclusion These findings indicate that leukocytes are one of the mediators that induce hepatic oxidative stress after renal IR. UR - https://ijbms.mums.ac.ir/article_5052.html L1 - https://ijbms.mums.ac.ir/article_5052_940b897778d61686c441fe27d7600324.pdf ER -