TY - JOUR ID - 5069 TI - Microinjection of NMDA Receptor Agents into the Central Nucleus of the Amygdale Alters Water Intake in Rats JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Solati, Jalal AU - Hajikhani, Ramin AD - Department of Biology, Faculty of Science, Karaj Islamic Azad University, Karaj, Iran AD - Department of Veterinary Medicine, Karaj Islamic Azad University, Karaj, Iran Y1 - 2010 PY - 2010 VL - 13 IS - 1 SP - 238 EP - 241 KW - Central amygdala KW - N-methyl-D-aspartate KW - Water intake DO - 10.22038/ijbms.2010.5069 N2 - Objective(s) The central nucleus of the amygdala (CeA) is a forebrain structure which is important in regulation of ingestive behavior and there is direct and circumstantial evidence to indicate that some circuits involved with feeding behavior include glutamatergic elements. The present study examined whether administration of NMA (N-Methyl-DL-aspartic acid) or MK801 into the CeA altered water intake under deprivation. Materials and Methods Animals were deprived for 24 hr before tested for water intake. NMDA (N-methyl-D-aspartate) glutamatergic receptor agonist, NMA and its antagonist, MK801 were infused bilaterally, and water intake measured for 1 hr thereafter. Results The intra-CeA injection of NMDA glutamatergic agonist, NMA (0.25, 0.5 and 0.75 pg/rat) increased water intake (P<0.05). However, administration of NMDA glutamatergic antagonist, MK801 (0.25, 0.5 and 1 pg/rat) decreased water intake significantly (P<0.05). Conclusion These data suggest that NMDA receptors in the CeA are responsible for the glutamatergic modulation of water intake in this nucleus. UR - https://ijbms.mums.ac.ir/article_5069.html L1 - https://ijbms.mums.ac.ir/article_5069_8ff3d14a016764242bb9a41508740094.pdf ER -