TY - JOUR ID - 5071 TI - Effects of Rat’s Licking Behavior on Cutaneous Wound Healing JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Abbasian, Behnam AU - Azizi, Shahrzad AU - Esmaeili, Abolghasem AD - Graduated of Faculty of Veterinary, Shahrekord Azad University, Shahrekord, Iran AD - Cell, Molecular & Developmental Division, Department of Biology, Faculty of Science, The University of Isfahan, Isfahan, Iran Y1 - 2010 PY - 2010 VL - 13 IS - 1 SP - 242 EP - 247 KW - Licking behavior KW - Rat KW - Saliva KW - Wound healing DO - 10.22038/ijbms.2010.5071 N2 - Objective(s) Wound licking has been shown to advance wound healing among humans and many other animals. The present study evaluates the licking effects on healing of skin wound in rats. Materials and Methods Twenty four rats were assigned to 4 different groups randomly and two 3 cm longitudinal full thickness incisions were made on each dorsal and ventral side of rats. The ventral incisions were considered as treated wounds because of contact to saliva as rats lick them easily and dorsal incisions as control wounds. Clinical changes and histopathological effects of rat saliva on wound healing were evaluated every day and on 3, 7, '4 and 2' days post-operation respectively. Results Histologic and clinical evaluation of treated wounds showed better healing than control wounds. Conclusion This study showed that licking behavior can promote wound healing. Thus salivary compounds could be isolated, be mass produced and may have potential to become as common as antibiotic cream. UR - https://ijbms.mums.ac.ir/article_5071.html L1 - https://ijbms.mums.ac.ir/article_5071_1688088bfe8eb215d9fc788c1919b286.pdf ER -