TY - JOUR ID - 5126 TI - Vitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Allahtavakoli, Mohammad AU - Pourshanazari, Aliasghar AU - Heshmatian, Behnam AD - Department of Physiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AD - Department of Physiology, School of Medicine, West Azarbaeejan University of Medical Sciences, Oroomiah, Iran Y1 - 2009 PY - 2009 VL - 12 IS - 1 SP - 9 EP - 17 KW - Alpha-tocotrienol KW - Cerebral ischemia KW - Embolic model KW - Neuroprotection KW - Vitamin E DO - 10.22038/ijbms.2009.5126 N2 - Objective(s) Previous studies have demonstrated that pretreatment with alpha-tocotrienol (a-TCT) can reduce ischemic damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease stroke- dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present study, the neuroprotective effects of a-TCT and rosiglitazone (RGZ) at 3 hr after cerebral ischemia were investigated. Materials and Methods Stroke was induced by embolizing a preformed clot into the MCA. Rats were assigned to vehicle, a-TCT (1 or 10 mg/kg), RGZ and sham-operation. Results Compared to the control group, only RGZ decreased infarct volume (P<0.05), neurological deficits (P<0.05) and sensory impairments (P<0.01) but low and high doses of a-TCT did not show any significant neuroprotective effect. Conclusion Our data showed that a-TCT was not neuroprotective at 3 hr after the embolic model of stroke. Further studies should be undertaken to clarify the neuroprotective effects of a-TCT after stroke. UR - https://ijbms.mums.ac.ir/article_5126.html L1 - https://ijbms.mums.ac.ir/article_5126_7008790dc1b24cdcf149d6b2c4060a0f.pdf ER -