TY - JOUR ID - 5204 TI - Pigment epithelium-derived factor: clinical significance in estrogen-dependent tissues and its potential in cancer therapy JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Franco-Chuaire, María Liliana AU - Ramírez-Clavijo, Sandra AU - Chuaire-Noack, Lilian AD - Departamento de Ginecología y Obstetricia, Hospital Mayor Mederi, Bogotá DC, Colombia AD - Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá DC, Colombia Y1 - 2015 PY - 2015 VL - 18 IS - 9 SP - 837 EP - 855 KW - Anti-tumorigenesis Antiangiogenesis KW - Estrogens KW - Estrogen receptors KW - Hormonal regulation KW - PEDF KW - Synthetic peptides DO - 10.22038/ijbms.2015.5204 N2 - Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the family of non-inhibitory serpins. The broad spectrum of PEDF biological activity is evident when considering its effects in promoting cell survival and proliferation, as well as its antiangiogenic, antitumor, and anti-metastatic properties. Although the structural domains of the PEDF gene that mediate such diverse effects and their mechanisms of action have not been completely elucidated, there is a large body of evidence describing their diverse range of activities; this evidence combined with the regulation of PEDF expression by sex steroids and their receptors have led to the idea that PEDF is not only a diagnostic and prognostic marker for certain diseases such as cancer, but is also a potential therapeutic target. In this manner, this paper aims to generally review the regulation of PEDF expression and PEDF interactions, as well as the findings that relate PEDF to the role of estrogens and estrogen receptors. In addition, this manuscript will review major advances toward potential therapeutic applications of PEDF. UR - https://ijbms.mums.ac.ir/article_5204.html L1 - https://ijbms.mums.ac.ir/article_5204_1d08a8f665e71babe42f741f43a00a02.pdf ER -