TY - JOUR ID - 5205 TI - Lack of FLT3-TKD835 gene mutation in toxicity of sulfur mustard in Iranian veterans JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Ayatollahi, Hossein AU - Rafiee, Mohammad AU - Keramati, Mohammad-Reza AU - Balali-Mood, Mahdi AU - Asgharzadeh, Ali AU - Sadeghian, Mohammad Hadi AU - Sheikhi, Maryam AU - Amini, Nafiseh AU - Moradi Zarmehri, Azam AD - Cancer Molecular Pathology Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Medical Toxicology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2015 PY - 2015 VL - 18 IS - 9 SP - 862 EP - 866 KW - FLT3-TKD835 mutation KW - Iran KW - Leukemia KW - Sulfur mustard DO - 10.22038/ijbms.2015.5205 N2 - Objective(s):Sulfur mustard (SM) was used by the Iraqi army against the Iranian troops in the Iran-Iraq war from 1983–1988. This chemical gas affects different organs including the skin, lungs and the hematopoietic system. Any exposure to SM increases the risk of chromosomal breaking, hyperdiploidy and hypodiploidy. Studies have shown that the risk for acute myeloblastic and lymphoblastic leukemia increases in veterans exposed to SM. FLT3 mutations including ITD and TKD mutations had been observed in some cases of leukemia. Therefore, we aimed to investigate the frequency of FLT3-TKD835 mutations in the veterans exposed to SM agent. Materials and Methods: We studied 42 patients who were exposed to SM during the war in Khorasan Razavi province, Mashhad, Iran in 2012. As control group, 30 healthy males were selected from first-degree relatives of the patients. For assessment of TKD835 mutation, DNA was extracted and RFLP-PCR was performed. Results: Analysis of RFLP-PCR data showed no FLT-3 TKD mutation in any of the patients. Conclusion: Although contact with SM can increase the risk of malignancy especially hematologic neoplasms, results of the study show that another mechanism of leukemogenesis, other than FLT3-TKD mutation, may be the reason for increased risk of leukemia in SM toxicity. UR - https://ijbms.mums.ac.ir/article_5205.html L1 - https://ijbms.mums.ac.ir/article_5205_f021bd52554bcd6dc98f627c9877b378.pdf ER -