TY - JOUR ID - 7138 TI - The protective effect of infliximab against carbon tetrachloride-induced acute lung injury JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Kurt, Aysel AU - Tumkaya, Levent AU - Yuce, Suleyman AU - Turut, Hasan AU - Cumhur Cure, Medine AU - Sehitoglu, Ibrahim AU - Kalkan, Yildiray AU - Pusuroglu, Gokhan AU - Cure, Erkan AD - Recep Tayyip Erdogan University, School of Medicine, Department of Thoracic Surgery, Rize, Turkey AD - Recep Tayyip Erdogan University, School of Medicine, Department of Histology and Embryology, Rize, Turkey AD - Department of Internal Medicine, Ordu Kumru State Hospital, Ordu, Turkey AD - Recep Tayyip Erdogan University, School of Medicine, Department of Biochemistry, Rize, Turkey AD - Recep Tayyip Erdogan University, School of Medicine, Department of Pathology, Rize, Turkey AD - Recep Tayyip Erdogan University, School of Medicine, Department of Internal Medicine, Rize, Turkey Y1 - 2016 PY - 2016 VL - 19 IS - 6 SP - 685 EP - 691 KW - Carbon tetrachloride KW - Infliximab KW - Nitric oxide KW - Pulmonary toxicity KW - Oxidative stress DO - 10.22038/ijbms.2016.7138 N2 - Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-α). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury. Materials and Methods:Rats were divided into control, CCl4, and CCl4+Ib groups. A single dose of 2 ml/kg CCI4 was administered to CCI4 group and a single dose of 7 mg/kg Ib was given to CCl4+Ib group 24 hr before applying CCI4. Results:TNF-α, malondialdehyde (MDA), nitric oxide (NO) and caspase-3 levels of the CCl4 group were markedly higher than both the control and CCl4+Ib groups. The CCI4+Ib group had lower histopathological injury than the CCl4 group. Conclusion:Ib as a strong TNF-α blocker decreases the production of proinflammatory cytokines, MDA, and oxidative stress leading to a protective effect against CCl4 induced lung tissue injury. UR - https://ijbms.mums.ac.ir/article_7138.html L1 - https://ijbms.mums.ac.ir/article_7138_3039f66c559f977304a83ed093dac0e2.pdf ER -