TY - JOUR ID - 7468 TI - The effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality in rat ovary JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Adebayo Kehinde, Babatunde AU - Abolhassani, Farid AU - Yazdekhasti, Hossein AU - Abbasi, Niloufar AU - Heydari, Leyla AU - Daneshi, Erfan AU - Rajabi, Zahra AU - Hamada, Alaa AU - Agarwal, Ashok AU - Abbasi, Mehdi AD - School of Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AD - Emergency Sections, Vali-Asr Hospital, Shahrekord University of Medical Sciences, Borujen, Iran AD - Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran AD - Department of Urology, St Elizabeth Medical Center, Tufts University, Brighton, MA, USA AD - American Center for Reproductive Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA Y1 - 2016 PY - 2016 VL - 19 IS - 8 SP - 863 EP - 869 KW - Antioxidant KW - Oocyte KW - Ovary KW - Varicose veins DO - 10.22038/ijbms.2016.7468 N2 - Objective(s): Several researchers have reported the relationship between infertility in male and varicocele for so many years but the implication of varicocele in female patients is remains elusive. Here, we aim to examine the effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality of rat ovary after the experimental creation of varicocele in female rats. Materials and Methods: In this study, thirty adult female albino rats were divided into three equal groups: Group 1 as the control group has 10 rats, Group 2 as the sham group has 10 rats and they underwent a sham operation and finally Group 3 has the varicocele group has 10 rats.  Antioxidant assays for superoxide dismutase, glutathioneperoxidase and catalase were performed using specific assay kits and gene expression for Bax, Bmp-15, Hsp-27 and Gdf-9 was done via real time PCR. Results: The adverse effects of the experimentally induced varicocele were reported and recorded on the left ovary compared to the right sided ovary (no varicocele induction) in the varicocele group. Real time PCR data shows that the expression of Gdf-9, Hsp-27 and Bmp-15 genes were all significantly reduced at P≤0.05. Conclusion: The results of this study show that reduced gene expression of Bmp-15, Gdf-9 and Hsp-27, increased gene expression of bax and an imbalance between pro-oxidant/ antioxidant ratio are few of the several mechanisms by which varicocele may lead to infertility in female. UR - https://ijbms.mums.ac.ir/article_7468.html L1 - https://ijbms.mums.ac.ir/article_7468_0750ee118762395b385f3d28d32c708c.pdf ER -