TY - JOUR ID - 7741 TI - The effect of Quercus brantii gall extract on burn wound healing in rat JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Haghdoost, Faraidoon AU - Baradaran Mahdavi, Mohammad Mehdi AU - Zolfaghari, Behzad AU - Sanei, Mohammad Hossein AU - Najafi, Somaye AU - Zandifar, Alireza AU - Manouchehri, Navid AU - Haghjooy Javanmard, Shaghayegh AD - Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran AD - Department of Pharmacognosy and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy, Isfahan University of Medical Sciences, HezarJarib Ave, Isfahan, Iran AD - Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran AD - Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran Y1 - 2016 PY - 2016 VL - 19 IS - 10 SP - 1144 EP - 1150 KW - Burn wound healing KW - Gall extract KW - Quercus Brantii DO - 10.22038/ijbms.2016.7741 N2 - Objective(s): The aim of the present study was to evaluate the effect of Quercus brantii galls extract on the rat skin burn wound healing. Materials and Methods: Ethanol extract of the galls of Q. brantii was used to treat the induced burn wounds on the back of 32 Wistar rats divided into 4 groups. The groups were treated by placebo, 1%, 2% and 4% concentration gall extract gels for 14 days and the efficacy of treatment was assessed based on reduction of burn wound area, as well as histological and molecular characteristics. Results: The mean wound surface in the 14th day, in all groups treated by Q. brantii gall extracts were larger than control group and the differences were statistically significant (P=0.043). The mean histological wound healing scores were not statistically different. Analysis of nitric oxide and platelet derived growth factor concentration in wound fluids in the 5th day of study showed that there was not any significant difference between groups (P=0.468 and 0.312 respectively). Fibroblast growth factor (bFGF) concentration in the wound fluids, was significantly higher in group treated with 1% gall extract gel in comparison to the control group (P=0.026). Conclusion: Our results could not prove the significant positive effect of Q. brantii galls extract on the burning wound healing. More studies with more groups treated with different doses of the Q. brantii extract are recommended. UR - https://ijbms.mums.ac.ir/article_7741.html L1 - https://ijbms.mums.ac.ir/article_7741_06c19fb3558c9a755de6e4e99032fcdc.pdf ER -