TY - JOUR ID - 8087 TI - Chronopharmacological effects of growth hormone on the executive function and oxidative stress response in rats JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Ferrari, Carlos K B AU - L França, Eduardo AU - A Monteiro, Luciane AU - L Santos, Bruno AU - Pereira-Junior, Alfredo AU - Honorio-França, Adenilda C AD - Federal University of Mato Grosso (UFMT), Mato Grosso, Brazil AD - University Center of Araxá (UNIARAXA), Minas Gerais, Brazil AD - São Paulo State University (UNESP), São Paulo, Brazil Y1 - 2017 PY - 2017 VL - 20 IS - 1 SP - 17 EP - 22 KW - Chronopharmacology KW - Executive function KW - Growth hormone KW - Superoxide anion KW - Superoxide Dismutase DO - 10.22038/ijbms.2017.8087 N2 - Objective(s): to investigate the chronopharmacological effects of growth hormone on executive function and the oxidative stress response in rats. Materials and Methods: Fifty male Wistar rats (36-40 weeks old) had ad libitum access to water and food and were separated into four groups: diurnal control, nocturnal control, diurnal GH-treated, and nocturnal GH-treated animals. Levels of Cu, Zn superoxide dismutase (Cu,Zn-SOD), and superoxide release by spleen macrophages were evaluated. For memory testing, adaptation and walking in an open field platform was used. GH-treated animals demonstrated better performance in exploratory and spatial open-field tests. Results: The latency time in both GH-treated groups was significantly lower compared with the latency time of the control groups. The diurnal GH treatment did not stimulate superoxide release but increased the CuZn-SOD enzyme levels. The nocturnal GH treatment did not influence the superoxide release and CuZn-SOD concentration. GH treatment also resulted in heart atrophy and lung hypertrophy. Conclusion: Growth hormone treatment improved the performance of executive functions at the cost of oxidative stress triggering, and this effect was dependent on the circadian period of hormone administration. However, GH treatment caused damaging effects such as lung hypertrophy and heart atrophy. UR - https://ijbms.mums.ac.ir/article_8087.html L1 - https://ijbms.mums.ac.ir/article_8087_252f5dfe6b4c4eba70b58ba1602ebfeb.pdf ER -