TY - JOUR ID - 8230 TI - Toxicology effects of saffron and its constituents: a review JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Badie Bostan, Hasan AU - Mehri, Soghra AU - Hosseinzadeh, Hossein AD - Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2017 PY - 2017 VL - 20 IS - 2 SP - 110 EP - 121 KW - Crocetin KW - Crocin KW - Saffron KW - Safranal KW - Toxicity DO - 10.22038/ijbms.2017.8230 N2 - Saffron (Crocus sativus L.) has been considered as a medicinal plant since ancient times and also widely used as food additive for its color, taste and odor. The pharmacological properties of saffron and its main constituents, crocin and safranal have been evaluated using different in vivo and in vitro models. Additionally, other lines of studies have found toxicological effects of saffron.  However, a comprehensive review that covers all aspects of its toxicity has not been published yet. The current study provides classified information about the toxic effects of saffron and its constituents in various exposure conditions including acute, sub-acute, sub-chronic and chronic studies. Therapeutic doses of saffron exhibits no significant toxicity in both clinical and experimental investigations. UR - https://ijbms.mums.ac.ir/article_8230.html L1 - https://ijbms.mums.ac.ir/article_8230_5bf447fc2fe20c473e8024c504bee251.pdf ER -