TY - JOUR ID - 8588 TI - Pharmacological effects of a synthetic quinoline, a hybrid of tomoxiprole and naproxen, against acute pain and inflammation in mice: a behavioral and docking study JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Hosseinzadeh, Hossein AU - Mazaheri, Fatemeh AU - Ghodsi, Razieh AD - Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AD - Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2017 PY - 2017 VL - 20 IS - 4 SP - 446 EP - 450 KW - Anti-inflammation KW - COX-2 KW - Molecular modeling KW - Naproxen KW - NSAIDs KW - Quinoline KW - Tomoxiprole DO - 10.22038/ijbms.2017.8588 N2 - Objective(s): In the present study, we investigated the potential anti-nociceptive activity and acute anti-inflammatory effect of a synthetic quinoline compound (2-(4-Methoxyphenyl)benzo[h]quinoline-4-carboxylic acid, QC), possessing structural elements of both naproxen and tomoxiprole drugs. Materials and Methods: The anti-nociceptive activity of QC was evaluated using chemical- and thermal-induced nociception models and its acute anti-inflammatory effect was evaluated by xylene-induced ear edema test in mice. Results: QC displayed a dose dependent effect in both acute anti-nociceptive tests (writhing and hot plate). This compound at dose of 6.562 mg/kg showed a high anti-nociceptive effect near equal to  diclofenac 5 mg/kg. It also showed high anti-inflammatory effects (less than 6.562 mg/kg) comparable to those of reference drugs diclofenac (5 mg/kg) and celecoxib (100 mg/kg). Docking study showed that this quinoline derivative could inhibit COX-2 enzyme strongly. Conclusion: QC showed high anti-nociceptive and anti-inflammatory effects comparable to reference drugs and can exert its anti-nociceptive and anti-inflammatory activities through COX-2 inhibition. UR - https://ijbms.mums.ac.ir/article_8588.html L1 - https://ijbms.mums.ac.ir/article_8588_8d117a69efc273e816e2d88f7e3bd345.pdf ER -