TY - JOUR ID - 9473 TI - Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Yang, Qiang AU - Wang, Wen-wen AU - Ma, Pu AU - Ma, Zhong-xuan AU - Hao, Meng AU - I Adelusi, Temitope AU - Du, Lei AU - Yin, Xiao-Xing AU - Lu, Qian AD - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221002, Jiangsu, China Y1 - 2017 PY - 2017 VL - 20 IS - 11 SP - 1220 EP - 1226 KW - GSK3β KW - insulin resistance KW - Swimming training KW - Type 2 diabetes mellitus KW - Wnt3a/β-catenin signaling DO - 10.22038/ijbms.2017.9473 N2 - Objective(s): Increasing evidence suggests that regular physical exercise improves type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T2DM, and its underlying mechanisms remain unclear. Materials and Methods: Rats were fed with high fat diet and given a low dosage of Streptozotocin (STZ) to induce T2DM model, and subsequently treated with or without swimming exercise. An 8-week swimming program (30, 60 or 120 min per day, 5 days per week) decreased body weight, fasting blood glucose and fasting insulin. Results: Swimming ameliorated lipid disorder, improved muscular atrophy and revealed a reduced glycogen deposit in skeletal muscles of diabetic rats. Furthermore, swimming also inhibited the activation of Wnt3a/β-catenin signaling pathway, decreased Wnt3a mRNA and protein level, upregulated GSK3β phosphorylation activity and reduced the expression of β-catenin phosphorylation in diabetic rats. Conclusion: The trend of the result suggests that swimming exercise proved to be a potent ameliorator of insulin resistancein T2DM through the modulation of Wnt3a/β-catenin pathway and therefore, could present a promising therapeutic measure towards the treatment of diabetes and its relatives. UR - https://ijbms.mums.ac.ir/article_9473.html L1 - https://ijbms.mums.ac.ir/article_9473_bde01bb94ca46a830cc593ec086dd912.pdf ER -