TY - JOUR ID - 9610 TI - Vitamin E improved bone strength and bone minerals in male rats given alcohol JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Zakaria, Syuhada AU - Mat-Husain, Siti-Zulaikha AU - Ying-Hwey, Kong AU - Xin-Kai, Kek AU - Mohd-Badawi, Abdullah AU - Abd-Ghani, Nurul-Amiza AU - Aziz, Muhamad-Arizi AU - Norazlina, Mohamed AD - Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia Y1 - 2017 PY - 2017 VL - 20 IS - 12 SP - 1360 EP - 1367 KW - Alcohol-induced disorder KW - Bone minerals KW - Bone strength KW - Palm oil KW - Vitamin E DO - 10.22038/ijbms.2017.9610 N2 - Objective(s): Alcohol consumption induces oxidative stress on bone, which in turn increases the risk of osteoporosis. This study determined the effects of vitamin E on bone strength and bone mineral content in alcohol-induced osteoporotic rats. Materials and Methods: Three months old Sprague Dawley male rats were randomly divided into 5 groups: (I) control group; (II) alcohol (3 g/kg) + normal saline; (III) alcohol (3 g/kg) + olive oil; (IV) alcohol (3 g/kg) + alpha-tocopherol (60 mg/kg) and (V) alcohol (3 g/kg) + palm vitamin E (60 mg/kg). The treatment lasted for three months. Following sacrifice, the right tibia was subjected to bone biomechanical test while the lumbar (fourth and fifth lumbar) and left tibia bones were harvested for bone mineral measurement. Results: Alcohol caused reduction in bone biomechanical parameters (maximum force, ultimate stress, yield stress and Young’s modulus) and bone minerals (bone calcium and magnesium) compared to control group (P<0.05). Palm vitamin E was able to improve bone biomechanical parameters by increasing the maximum force, ultimate stress and Young’s modulus (P<0.05) while alpha-tocopherol was not able to. Both alpha-tocopherol and palm vitamin E were able to significantly increase tibia calcium and magnesium content while only alpha-tocopherol caused significant increase in lumbar calcium content (P<0.05). Conclusion: Both palm vitamin E and alpha-tocopherol improved bone mineral content which was reduced by alcohol. However, only palm vitamin E was able to improve bone strength in alcohol treated rats. UR - https://ijbms.mums.ac.ir/article_9610.html L1 - https://ijbms.mums.ac.ir/article_9610_80ac61f046bcb1607e993060bf81f0c3.pdf ER -