TY - JOUR ID - 9918 TI - Protective effect of metformin on D-galactose-induced aging model in mice JO - Iranian Journal of Basic Medical Sciences JA - IJBMS LA - en SN - 2008-3866 AU - Fatemi, Iman AU - khaluoi, Amin AU - Kaeidi, Ayat AU - Shamsizadeh, Ali AU - Heydari, Sara AU - Allahtavakoli, Mohammad AD - Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Y1 - 2018 PY - 2018 VL - 21 IS - 1 SP - 19 EP - 25 KW - Aging KW - D-galactose KW - Metformin KW - Mouse KW - Oxidative stress DO - 10.22038/ijbms.2017.24331.6071 N2 - Objective(s): Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. Materials and Methods: Met (1 and 10 mg/kg/p.o.), was administrated daily in D-gal-received (500 mg/kg/p.o.) mice model of aging for six weeks. Anxiety-like behavior, cognitive function, and physical power were evaluated by the elevated plus-maze, novel object recognition task (NORT), and forced swimming capacity test, respectively. The brains were analyzed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF). Results: Met decreased the anxiety-like behavior in D-gal-treated mice. Also, Met treated mice showed significantly improved learning and memory ability in NORT compared to the D-gal-treated mice. Furthermore, Met increased the physical power as well as the activity of SOD and BDNF level in D-gal-treated mice. Conclusion: Our results suggest that the use of Met can be an effective strategy for prevention and treatment of D-gal-induced aging in animal models. This effect seems to be mediated by attenuation of oxidative stress and enhancement of the neurotrophic factors. UR - https://ijbms.mums.ac.ir/article_9918.html L1 - https://ijbms.mums.ac.ir/article_9918_8485c501384b5a8c6369749b6ca9f3f6.pdf ER -