Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice

Authors

1 Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

2 Department of Chemistry, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

3 Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Abstract

 




Objective(s): Because of the high total phenolic contents of Feijoa sellowiana
, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice.
 
Materials and Methods:
Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana
leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was injected. Nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. Histopathological study was also used.
 
Results
 
: Both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (P <0.05). Not statistically significant was observed in effect of two extracts (P>0.05). A decrease in urea/ creatinine ratio was observed following aqueous extract treatment. Methanolic extract showed higher activity in increasing kidney glutathione (P

Conclusion:
 
F. sellowiana extract resulted in a markedly decrease in the nephrotoxicity of MDMA in mice.

Keywords


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