A Comparative Study of Serum Level of Vascular Cell Adhesion Molecule-1 (sVCAM-1), Intercellular Adhesion Molecule-1(ICAM-1) and High Sensitive C - reactive protein (hs-CRP) in Normal and Pre-eclamptic Pregnancies

Document Type: Original Article

Authors

1 Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,3Cancer Molecular Pathology Research Centre, Mashhad University of Medical Sciences. Mashhad, Iran

2 Departments of Hematopathology and Blood Banking; Faculty of Medicine, Mashhad University of Medical Sciences. Mashhad, Iran 3Cancer Molecular Pathology Research Centre, Mashhad University of Medical Sciences. Mashhad, Iran

3 Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences. Mashhad, Iran

4 Student Research Committee, Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences. Mashhad, Iran

Keywords


1. Gearing AJ, Newman W. Circulating adhesion molecules in disease. Immunol Today  1993; 14:506-512.

2. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol  1989; 161:1200-1024.

3. Dekker GA, Sibai BM. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol  1998; 179:1359-1275.

4. Sacks GP, Studena K, Sargent K, Redman CW. Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis. Am J Obstet Gynecol  1998; 179:80-86.

5. Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol  2003; 102:181-192.

6. Ridker PM, Glynn RJ, Hennekens CH. C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation  1998; 97):2007-5011.

7. Teran E, Escudero C, Moya W, Flores M, Vallance P, Lopez-Jaramillo P. Elevated C-reactive protein and pro-inflammatory cytokines in Andean women with pre-eclampsia. Int J Gynaecol Obstet  2001 ; 75:243-249.

8. Yu H, Rifai N. High-sensitivity C-reactive protein and atherosclerosis: from theory to therapy. Clin Biochem  2000; 33:601-610.

9. Hwang HS, Kwon JY, Kim MA, Park YW, Kim YH. Maternal serum highly sensitive C-reactive protein in normal pregnancy and pre-eclampsia. Int J Gynaecol Obstet  2007; 98:105-109.

10. Cunningham FG, Williams JW, Leveno KJ, Bloom S, Hauth JC, Rouse DJ. Williams obstetrics. 23 ed. McGraw-Hill Medical; 2009.

11. Freeman DJ, McManus F, Brown EA, Cherry L, Norrie J, Ramsay JE, et al. Short- and long-term changes in plasma inflammatory markers associated with preeclampsia. Hypertension  2004 ; 44:708-714.

12. Ramma W, Ahmed A. Is inflammation the cause of pre-eclampsia? Biochem Soc Trans 2011  ; 39:1619-1627.

13. Ahmed A. New insights into the etiology of preeclampsia: identification of key elusive factors for the vascular complications. Thromb Res 2011; 127:S72-75.

14. Friedman SA, Taylor RN, Roberts JM. Pathophysiology of preeclampsia. Clin Perinatol 1991 ; 18:661-682.

15. Roberts JM. Endothelial dysfunction in preeclampsia. Semin Reprod Endocrinol  1998; 16:5-15.

16. Mantovani A, Dejana E. Cytokines as communication signals between leukocytes and endothelial cells. Immunol Today  1989; 10:370-375.

17. Greer IA, Dawes J, Johnston TA, Calder AA. Neutrophil activation is confined to the maternal circulation in pregnancy-induced hypertension. Obstet Gynecol  1991; 78:28-32.

18. Molvarec A, Szarka A, Walentin S, Beko G, Karadi I, Prohaszka Z, et al. Serum leptin levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in normal pregnancy and preeclampsia. Reprod Biol Endocrinol  2011; 9:124.

19. Higgins JR, Papayianni A, Brady HR, Darling MR, Walshe JJ. Circulating vascular cell adhesion molecule-1 in pre-eclampsia, gestational hypertension, and normal pregnancy: evidence of selective dysregulation of vascular cell adhesion molecule-1 homeostasis in pre-eclampsia. Am J Obstet Gynecol  1998; 179:464-469.

20. Austgulen R, Lien E, Vince G, Redman CW. Increased maternal plasma levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in preeclampsia. Eur J Obstet Gynecol Reprod Biol  1997 ; 71:53-58.

21. Krauss T, Osmers R, Beran J, Diedrich F, Fleckenstein G, Kuhn W. [Soluble adhesion molecules in patients with pre-eclampsia]. Zentralbl Gynakol  1998; 120:279.

22. Daniel Y, Kupferminc M, Baram A, Jaffa A, Wolman I, Shenhav M, et al. Plasma soluble endothelial selectin is elevated in women with pre-eclampsia. Hum Reprod  1998; 13:3537-3541.

23. Krauss T, Azab H, Dietrich M, Augustin HG. Fetal plasma levels of circulating endothelial cell adhesion molecules in normal and preeclamptic pregnancies. Eur J Obstet Gynecol Reprod Biol  1998 ; 78:41-45.

24. Lyall F, Greer IA, Boswell F, Macara LM, Walker JJ. The cell adhesion molecule, VCAM‐1, is selectively elevated in serum in pre‐eclampsia: does this indicate the mechanism of leucocyte activation? Br J Obstet Gynaecol  1994; 101:485-487.

25. Farzadnia M, Ayatollahi H, Maliheh HM, Rahimi HR. A comparative study of serum soluble vascular cell adhesion molecule-1(svcam-1) and intercellular adhesion molecule-1(icam-1) in normal pregnant adhesion molecule-1(icam-1) in normal pregnancy. Clin Biochem 2011; 44:S163.

26. Zeisler H, Livingston JC, Schatten C, Tempfer C, Knofler M, Husslein P. Serum levels of adhesion molecules in women with pregnancy-induced hypertension. Wien Klin Wochenschr. 2001; 113:588-592.

27. Chaiworapongsa T, Romero R, Yoshimatsu J, Espinoza J, Kim YM, Park K, et al. Soluble adhesion molecule profile in normal pregnancy and pre-eclampsia. J Matern Fetal Neonatal Med 2002 ; 12:19-27.

28. Madazli R, Budak E, Calay Z, Aksu MF. Correlation between placental bed biopsy findings, vascular cell adhesion molecule and fibronectin levels in pre-eclampsia. BJOG  2000; 107:514-518.

29. Ley K, Huo Y. VCAM-1 is critical in atherosclerosis. J Clin Invest  2001; 107:1209-1210.

30. Krauss T, Emons G, Kuhn W, Augustin HG. Predictive value of routine circulating soluble endothelial cell adhesion molecule measurements during pregnancy. Clin Chem 2002; 48:1418-425.

31. Chavarría ME, Lara-González L, García-Paleta Y, Vital-Reyes VS, Reyes A. Adhesion molecules changes at 20 gestation weeks in pregnancies complicated by preeclampsia. Eur J Obstet Gynecol Reprod Biol  2008; 137:157-164.

32. Redman CW, Sacks GP, Sargent IL. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol  1999; 180:499-506.

33. Du Clos TW. The interaction of C-reactive protein and serum amyloid P component with nuclear antigens. Mol Biol Rep  1996; 23:253-260.

34. Tjoa ML, van Vugt JM, Go AT, Blankenstein MA, Oudejans CB, van Wijk IJ. Elevated C-reactive protein levels during first trimester of pregnancy are indicative of preeclampsia and intrauterine growth restriction. J Reprod Immunol  2003; 59:29-37.

35. Savvidou MD, Lees CC, Parra M, Hingorani AD, Nicolaides KH. Levels of C-reactive protein in pregnant women who subsequently develop pre-eclampsia. BJOG  2002; 109:297-301.