@article { author = {Gholamnezhad, Zahra and Koushyar, Hamed and Byrami, Goltaj and Boskabady, Mohammad Hossein}, title = {The Extract of Crocus sativus and Its Constituent Safranal, Affect Serum Levels of Endothelin and Total Protein in Sensitized Guinea Pigs}, journal = {Iranian Journal of Basic Medical Sciences}, volume = {16}, number = {9}, pages = {1022-1026}, year = {2013}, publisher = {Mashhad University of Medical Sciences}, issn = {2008-3866}, eissn = {2008-3874}, doi = {10.22038/ijbms.2013.1685}, abstract = {  Objective(s): The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined.   Materials and Methods: Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, three concentrations of extract and one concentration of dexamethasone, (n=6, for all groups) and serum levels of endotheline-1 (ET-1) and total protein (TP) were assessed. Results: Serum levels of ET-1 and TP in group S were significantly higher than control group (P Conclusion: A preventive effect of the extract of C. sativus and its constituent safranal on serum inflammatory markers in sensitized guinea pigs was shown. }, keywords = {Asthma Crocus sativus Endotheline Inflammation Safranal Sensitization}, url = {https://ijbms.mums.ac.ir/article_1685.html}, eprint = {https://ijbms.mums.ac.ir/article_1685_ae4fd56a01345f39e341f37664d44da1.pdf} }