@article { author = {Askarian-Amiri, Shaghayegh and Fotovat eskandari, Hoda and Ramezani, Fatemeh and Vahabzadeh, Gelare and Aboutaleb, Nahid}, title = {Lavender protects H9c2 cardiomyocytes against oxygen-glucose deprivation (OGD)-induced injury via targeting the JAK2/STAT3 pathway}, journal = {Iranian Journal of Basic Medical Sciences}, volume = {25}, number = {2}, pages = {263-267}, year = {2022}, publisher = {Mashhad University of Medical Sciences}, issn = {2008-3866}, eissn = {2008-3874}, doi = {10.22038/ijbms.2022.54751.12280}, abstract = {Objective(s): This study was conducted to examine the therapeutic effects of lavender oil (LO) against oxygen-glucose deprivation (OGD)-induced injury in vitro model.Materials and Methods: In this study, the OGD model was induced in the H9C2 cell line, and then the cells were treated with LO (10, 100, 1000, and 10000 μg/ml). The anti-inflammatory activity of LO (Jak2/Stat3) was evaluated by immunocytochemical assay. Likewise, the p-ERK/ERK level was measured by western blotting.Results: Compared with only the OGD-induced injury model, cell survival increased after treatment with LO. Our results showed that 100 μg/ml of LO significantly decreased the expression of Jak2/Stat3 and the apoptotic activity 72 hr after reperfusion compared with the control group. Likewise, significant increases were observed in p-ERK/ERK in LO-treated groups. Conclusion: Collectively, these findings confirm that LO can be a good candidate to reduce OGD-induced injury in the H9C2 cell line through targeting Jak2/Stat3 and ERK pathways.}, keywords = {H9C2 cells,Inflammation,Ischemia/Reperfusion injury,Jak2 / Stat3,Lavender oil,p-ERK / ERK}, url = {https://ijbms.mums.ac.ir/article_19589.html}, eprint = {https://ijbms.mums.ac.ir/article_19589_c2fea7e8ca66e5c324d67ab83a149042.pdf} }