@article { author = {Haghshenas, Rouhollah and Jafari, Mahvash and Ravasi, Aliasghar and Kordi, Mohammadreza and Gilani, Neda and Shariatzadeh, Mohammad and Hedayati, Mehdi and Rahimi, Mostafa}, title = {The effect of eight weeks endurance training and high-fat diet on appetite-regulating hormones in rat plasma}, journal = {Iranian Journal of Basic Medical Sciences}, volume = {17}, number = {4}, pages = {237-243}, year = {2014}, publisher = {Mashhad University of Medical Sciences}, issn = {2008-3866}, eissn = {2008-3874}, doi = {10.22038/ijbms.2014.2580}, abstract = {Objective(s):Consumption of high-fat foods is one of the major causes of obesity. Physical exercise is a strategy used to counteract obesity. The aim of this study was to investigate the effect of eight weeks endurance training and high-fat diet (HFD) on appetite-regulating hormones in rat plasma. Materials and Methods:Twenty eight male Wistar rats were randomly divided into four groups: Control group with standard diet (CSD), endurance training with a standard diet (ESD), control group with high-fat diet (CHFD) and endurance training with high-fat diet (EHFD). Twenty-four hr after the last training session, the blood samples were obtained and analyzed for hormones levels. Results: The significant increased weight gain and food intake and decreased plasma nesfatin-1 and PYY3-36 levels were observed in CHFD group, while exercise under the HFD antagonized these effects. There were no significant changes in ghrelin, insulin and leptin levels in different groups. Conclusion: These results suggest that exercise can prevent fattening effect of HFD. Probably, performing exercise makes a reduction of food intake and weight gain in rat via the increase in nesfatin-1 and PYY levels. However, further studies are necessary to understand the exact mechanisms involved in this field.}, keywords = {Endurance training,Food intake,High fat diet,Peptide hormones}, url = {https://ijbms.mums.ac.ir/article_2580.html}, eprint = {https://ijbms.mums.ac.ir/article_2580_6d18467fe2598e3ef5154f6f47485792.pdf} }