@article { author = {Mansouri, Esrafil and Khorsandi, Layasadat and Abedi, Hassan Ali}, title = {Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats}, journal = {Iranian Journal of Basic Medical Sciences}, volume = {17}, number = {6}, pages = {460-464}, year = {2014}, publisher = {Mashhad University of Medical Sciences}, issn = {2008-3866}, eissn = {2008-3874}, doi = {10.22038/ijbms.2014.2932}, abstract = {Objective(s):Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. Materials and Methods: Thirty male Sprague–Dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with GSP. Diabetes was induced in rats by intraperitoneal injection of streptozotocin (50 mg/kg). GSP were administered via oral gavage (200 mg/kg) for 4 weeks. Results: GSP produced significant hepatoprotective effects by decreasing activities of serum aminotransferases and alkaline phosphatase, and decreasing liver malondialdehyde and bilirubin (P<0.05) levels. It increased liver superoxide dismutase, catalase and glutathione peroxidase activities and albumin level (P<0.05). Administration of GSP significantly ameliorated structural changes induced in liver of diabetic rats. Conclusion: GSP have protective effects against hepatic tissue injury due to antioxidant properties.}, keywords = {Antioxidant enzyme,Diabetes,GSP,Hepatic tissue}, url = {https://ijbms.mums.ac.ir/article_2932.html}, eprint = {https://ijbms.mums.ac.ir/article_2932_4b370f73091baabac68fd27b43411d73.pdf} }