@article { author = {Boskabady, Mohammad Hossein and Vatanprast, Alaleh and Parsee, Hydar and Ghasemzadeh, Mahbobeh}, title = {Effect of Aqueous-Ethanolic Extract from Rosa damascena on Guinea Pig Isolated Heart}, journal = {Iranian Journal of Basic Medical Sciences}, volume = {14}, number = {2}, pages = {116-121}, year = {2011}, publisher = {Mashhad University of Medical Sciences}, issn = {2008-3866}, eissn = {2008-3874}, doi = {10.22038/ijbms.2011.4974}, abstract = {Objective(s) In the present study, the effects of aqueous-ethanolic extract from Rosa damascena on heart rate and contractility were examined. Materials and Methods Isolated guinea-pig hearts were perfused through aorta in a Langendorff mode. Heart rate (HR) and contractility were determined in the presence of four concentrations of the extract (0.1, 0.2, 0.4 and 1.0 mg %) and isoprenaline (1, 10, 100 nM and 1 μM) in comparison with baseline values in the presence and absence of propranolol (n= 10 for each group). Results Both isoprenaline and the extract caused increase in heart rate and contractility (P< 0.05 to P< 0.001). The percent increased in HR due to the final concentration of isoprenaline in the absence of propranolol was significantly greater than that of the extract (P< 0.01). Propranolol caused significant reduction in both HR and contractility (P< 0.05 for both) but this effect was significantly reversed by isoprenaline and the extract (P< 0.05 to P< 0.001). The percent increased in heart contractility due to the final concentration of the extract in the absence and presence of propranolol was significantly greater than that of isoprenaline (P< 0.05 for both cases). There was significant correlation between both HR and heart contractility with concentration of isoprenaline and the extract (P< 0.05 to P< 0.001). Conclusion In conclusion this study showed a relatively potent inotropic and chornotropic effect for Rosa damascena on isolated guinea-pig heart.}, keywords = {Aqueous-ethanolic extract,β-adrenoceptor,Guinea-pig,Isolated heart,Rosa damascena}, url = {https://ijbms.mums.ac.ir/article_4974.html}, eprint = {https://ijbms.mums.ac.ir/article_4974_b5786e54d5f09ee5bee192fb0848d95d.pdf} }