@article { author = {Hosseinzadeh, Hossein and Mazaheri, Fatemeh and Ghodsi, Razieh}, title = {Pharmacological effects of a synthetic quinoline, a hybrid of tomoxiprole and naproxen, against acute pain and inflammation in mice: a behavioral and docking study}, journal = {Iranian Journal of Basic Medical Sciences}, volume = {20}, number = {4}, pages = {446-450}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2008-3866}, eissn = {2008-3874}, doi = {10.22038/ijbms.2017.8588}, abstract = {Objective(s): In the present study, we investigated the potential anti-nociceptive activity and acute anti-inflammatory effect of a synthetic quinoline compound (2-(4-Methoxyphenyl)benzo[h]quinoline-4-carboxylic acid, QC), possessing structural elements of both naproxen and tomoxiprole drugs. Materials and Methods: The anti-nociceptive activity of QC was evaluated using chemical- and thermal-induced nociception models and its acute anti-inflammatory effect was evaluated by xylene-induced ear edema test in mice. Results: QC displayed a dose dependent effect in both acute anti-nociceptive tests (writhing and hot plate). This compound at dose of 6.562 mg/kg showed a high anti-nociceptive effect near equal to  diclofenac 5 mg/kg. It also showed high anti-inflammatory effects (less than 6.562 mg/kg) comparable to those of reference drugs diclofenac (5 mg/kg) and celecoxib (100 mg/kg). Docking study showed that this quinoline derivative could inhibit COX-2 enzyme strongly. Conclusion: QC showed high anti-nociceptive and anti-inflammatory effects comparable to reference drugs and can exert its anti-nociceptive and anti-inflammatory activities through COX-2 inhibition.}, keywords = {Anti-inflammation,COX-2,Molecular modeling,Naproxen,NSAIDs,Quinoline,Tomoxiprole}, url = {https://ijbms.mums.ac.ir/article_8588.html}, eprint = {https://ijbms.mums.ac.ir/article_8588_8d117a69efc273e816e2d88f7e3bd345.pdf} }