%0 Journal Article %T The effects of bortezomib on the ovariectomy applied rat uterus: A histopathological, stereological and immunohistochemical study %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Khoshvaghti, Habib %A Altunkaynak, Berrin Zuhal %D 2018 %\ 11/01/2018 %V 21 %N 11 %P 1118-1125 %! The effects of bortezomib on the ovariectomy applied rat uterus: A histopathological, stereological and immunohistochemical study %K Bortezomib Microscopy Ovariectomy Rat Stereology %K Uterus %R 10.22038/ijbms.2018.24756.6152 %X Objective(s): In this study, potential protective effects of Bortezomib (Bort), as a proteasome inhibitor, were investigated on the uterus of ovariectomized rats by histological, morphometric and immunohistochemical methods.Materials and Methods: In this study, 18 Sprague dawley strain female rats (12 weeks old, 250-300 g body weight) were used. Animals in the control group (Cont, n=6) were not exposed to any treatment. Ovariectomy was performed on the experimental groups. They (n=12) were divided into ovariectomy (Ovt, n=6) and Bortezomib (Bort, n=6) subgroups. Twelve weeks later, the rats were perfused. Then, uterine tissues were removed and examined by morphometrical, and light and electron microscopy methods. In addition, immunoreactivity of nuclear factor-kappa (NF-κB) was evaluated.Results: Morphometric and histopathological evaluations showed that Bort was effective in the uterus and protects the layer structures and the cells.Conclusion: In the light of these findings, we suggest that for proteasome inhibitor particularly Bort is thought to be useful through proteasome inhibition and NF-κB pathway. %U https://ijbms.mums.ac.ir/article_11546_f392db9030f233af4ece5140662beb4b.pdf