%0 Journal Article %T Generation of motor neurons from human amygdala-derived neural stem-like cells %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Ghasemi, Sepideh %A Aligholi, Hadi %A Koulivand, Pir Hossain %A Jafaraian, Maryam %A Hosseini Ravandi, Hassan %A Khaleghi Ghadiri, Maryam %A Gorji, Ali %D 2018 %\ 11/01/2018 %V 21 %N 11 %P 1155-1160 %! Generation of motor neurons from human amygdala-derived neural stem-like cells %K Brain %K Hippocampus %K Intractable epilepsy %K Motor Neuron %K Neural stem cells %R 10.22038/ijbms.2018.29587.7146 %X Objective(s): Among several cell sources, adult human neural stem/progenitor cells (hNS/PCs) have been considered outstanding cells for performing mechanistic studies in in vitro and in vivo models of neurological disorders as well as for potential utility in cell-based therapeutic approaches. Previous studies addressed the isolation and culture of hNS/PCs from human neocortical and hippocampal tissues. However, little data are available on hNS/PCs obtained from the adult human amygdala.Materials and Methods: The present study explored the capacity of the amygdala harvested from resected brain tissues of patients with medically refractory epilepsy to generate neurosphere-like bodies and motor neuron-like cells.Results: Although the proliferation process was slow, a considerable amount of cells was obtained after the 3rd passage. In addition, the cells could generate motor neuron-like cells under appropriate culture conditions. Conclusion: Isolation and culture of these cells enable us to improve our knowledge of the role of the amygdala in some neurological and psychological disorders and provide a novel source for therapeutic cell transplantation. %U https://ijbms.mums.ac.ir/article_11548_a7bde3b2eda8806114262f5bd4e373cf.pdf