%0 Journal Article %T Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol consumption %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Lin, Chun-Che %A Yang, Ya-Chen %A Chen, Chia-Yu %A Yin, Mei-Chin %D 2021 %\ 08/01/2021 %V 24 %N 8 %P 1146-1152 %! Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol consumption %K Ethanol Hepatic steatosis Myeloperoxidase Protocatechuic acid S %K methyl cysteine %R 10.22038/ijbms.2021.56705.12660 %X Objective(s): Protective effects of s-methyl cysteine (SMC) alone, protocatechuic acid (PCA) alone, and SMC plus PCA against chronic ethanol consumption induced hepatic steatosis and inflammation were investigated.  Materials and Methods: Mice were divided into six groups: normal diet (ND) group, Lieber-DeCarli liquid diet without ethanol (LD diet) group, LD diet with ethanol (LED diet) group, SMC group (LED diet plus 0.25% SMC), PCA group (LED diet plus 0.25% PCA), and SMC+PCA group (LED diet plus 0.125% SMC + 0.125% PCA).  After 8 weeks of supplementation, blood and liver were used for analysis.  Results: Biochemical and histological data showed that SMC plus PCA led to a greater reduction in lipid droplets in the liver than SMC or PCA treatment alone.  SMC plus PCA resulted in greater suppression in hepatic mRNA expression of peroxisome proliferator-activated receptor-gamma, sterol regulatory element-binding protein 1c, stearoyl-CoA desaturase-1, cyclooxygenase-2, and myeloperoxidase than SMC or PCA treatment alone.  SMC plus PCA led to a greater decrease in hepatic reactive oxygen species and inflammatory cytokine levels than SMC or PCA treatment alone.  Conclusion: These novel findings suggest that the combination of SMC and PCA was a potent remedy for alcoholic liver disorders. %U https://ijbms.mums.ac.ir/article_18418_c699e09113f50fe8aede6f14678c9688.pdf