%0 Journal Article %T Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Hu, Liandong %A Hu, Qiaofeng %A Yang, Jianxue %D 2014 %\ 10/01/2014 %V 17 %N 10 %P 760-766 %! Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle %K Ibuprofen %K Microemulsion %K Skin Permeability %K Transdermal %R 10.22038/ijbms.2014.3450 %X Objective(s):The objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability. Materials and Methods: Microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. The effects of oleic acid and surfactant mixture on skin permeation of ibuprofen were evaluated with excised skins. Results: The optimum formulation F3 consisting of 6% oleic acid, 30% Cremophor RH40/Transcutol P (2:1, w/w) and 59% water phase, showed a high permeation rate of 42.98 μg/cm2/hr. The mean droplet size of microemulsion was about 43 nm and no skin irritation signs were observed on the skin of rabbits. Conclusion: These results indicated that this novel microemulsion is a useful formulation for the transdermal delivery of ibuprofen. %U https://ijbms.mums.ac.ir/article_3450_4d19d9c3f1512652651843aec5101b69.pdf