%0 Journal Article %T Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Tafreshian, Amir Reza %A Etemadi, Mehdi %A Farid-Hosseini, Reza %A Salhi, Mansoor %A Tavakkol Afshari, Jalil %D 2014 %\ 10/01/2014 %V 17 %N 10 %P 798-801 %! Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province %K HLA %K HLA-DQB1 %K HAM/TSP %K HTLV-1 %K PCR-SSP %R 10.22038/ijbms.2014.3456 %X Objective(s): HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases.  Among the genes are involved in HTLV-I infection, the role of human leukocytes antigen (HLA) have been studied in different population. In the present study we examined the association between HLA-DQB1 alleles and HTLV-I infection in HAM/TSP patients, HTLV-I carriers and healthy controls in north east of Iran, Mashhad. Materials and Methods:The blood samples of 16 patients with HAM/TSP, 20 HTLV-1 carriers, and 30 healthy individuals were taken and DNA was extracted by salting out method.  HLA-DQB1 typing was performed using PCR-SSP method and the frequency of HLA-DQB1 alleles were compared by Fischer Exact Test. Results:There was a significant difference between HAM/TSP patients and healthy controls in the frequency of HLA-DQB1*07 (P=0.004, RR=7). Furthermore, we found that possession of HLA- DQB1*02 or HLA-DQB1*05 increased the risk of disease 1.5 times. Conclusion: The data presented here suggest that both HLA-DQB1*07 and HLA-DQB1*06 are associated with disease development. %U https://ijbms.mums.ac.ir/article_3456_db24c5d4a1ca88ab99a639b07c0f9ae2.pdf