%0 Journal Article %T Vitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats %J Iranian Journal of Basic Medical Sciences %I Mashhad University of Medical Sciences %Z 2008-3866 %A Allahtavakoli, Mohammad %A Pourshanazari, Aliasghar %A Heshmatian, Behnam %D 2009 %\ 01/01/2009 %V 12 %N 1 %P 9-17 %! Vitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats %K Alpha-tocotrienol %K Cerebral ischemia %K Embolic model %K Neuroprotection %K Vitamin E %R 10.22038/ijbms.2009.5126 %X Objective(s) Previous studies have demonstrated that pretreatment with alpha-tocotrienol (a-TCT) can reduce ischemic damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease stroke- dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present study, the neuroprotective effects of a-TCT and rosiglitazone (RGZ) at 3 hr after cerebral ischemia were investigated. Materials and Methods Stroke was induced by embolizing a preformed clot into the MCA. Rats were assigned to vehicle, a-TCT (1 or 10 mg/kg), RGZ and sham-operation. Results Compared to the control group, only RGZ decreased infarct volume (P<0.05), neurological deficits (P<0.05) and sensory impairments (P<0.01) but low and high doses of a-TCT did not show any significant neuroprotective effect. Conclusion Our data showed that a-TCT was not neuroprotective at 3 hr after the embolic model of stroke. Further studies should be undertaken to clarify the neuroprotective effects of a-TCT after stroke. %U https://ijbms.mums.ac.ir/article_5126_7008790dc1b24cdcf149d6b2c4060a0f.pdf